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KMID : 0043319930160020159
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Archives of Pharmacal Research
1993 Volume.16 No. 2 p.159 ~ p.160
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A Facile Synthetic Method of 2-Oxaxolidinones and 1,3-Oxazine-2-ones, Essential Moieties of New Antiulcer Agent
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Park Min-Soo
Lee Jae-Won
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Abstract
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2-Oxazolidinones and 1,3-oxazine-2-ones, key moieties of new antiulcer agents, were prepared successfully by treating corresponding hydroxyamide with N-bromosuccinimide (NBS) and silveracetate in acetonitrile. From the fact that the methods for the preparation of hydoxy amides are versatile and such amides could be converted to the corresponding 2-oxazolid-iones and 1,3-oxazine-2-one under our reaction condition, we think that our method is very practical one for the preparation of such compounds. In addition, the above synthetic example affords a good evidence of the synthetic applicability of our improved Hofmann rearrangement.
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KEYWORD
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2-Oxazolidinone, 1, 3-Oxazine-2-one, 3-Hydroxyamide, 4-Hydroxyamide, N-Bromo-succinimide, Antulcer agent, Hofmann rearrangement
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